HRID905547

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCN(C)C(=O)N4C3)nccc2c1

HCID67387741

未命名化合物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCN(C)C(=O)N4C3)nc(Cl)cc2c1

HCID76674828

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)NS(=O)(=O)C6CC6)CC5C=CCCCCN(C)C(=O)N4C3)nc(-c3ccccc3)cc2c1

HCID67387505

未命名化合物

PROCEDURE

实验过程

The title product 56 was prepared from 17-(6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (55) following the same procedures described for the preparation of N-[17-(3-chloro-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo-[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide (43, Example 11): m/z=688.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0ce9ed3a09744341b602dbffe92aeea0
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08012939B2
来源说明: uspto-grants-2011_09

反应 SMILES

CO[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)C(OC1CC3N(C(=O)N(C)CCCCC=CC4C(C(O)=O)(NC3=O)C4)C1)=NC=C2.Cl[C:39]1[N:40]=[C:41]([O:51][CH:52]2[CH2:69][CH:68]3[N:54]([C:55](=[O:81])[N:56]([CH3:80])[CH2:57][CH2:58][CH2:59][CH2:60][CH:61]=[CH:62][CH:63]4[C:65]([C:71]([NH:73][S:74]([CH:77]5[CH2:79][CH2:78]5)(=[O:76])=[O:75])=[O:72])([NH:66][C:67]3=[O:70])[CH2:64]4)[CH2:53]2)[C:42]2[C:47]([CH:48]=1)=[CH:46][C:45]([O:49][CH3:50])=[CH:44][CH:43]=2>>[C:3]1([C:39]2[N:40]=[C:41]([O:51][CH:52]3[CH2:69][CH:68]4[N:54]([C:55](=[O:81])[N:56]([CH3:80])[CH2:57][CH2:58][CH2:59][CH2:60][CH:61]=[CH:62][CH:63]5[C:65]([C:71]([NH:73][S:74]([CH:77]6[CH2:79][CH2:78]6)(=[O:75])=[O:76])=[O:72])([NH:66][C:67]4=[O:70])[CH2:64]5)[CH2:53]3)[C:42]3[C:47]([CH:48]=2)=[CH:46][C:45]([O:49][CH3:50])=[CH:44][CH:43]=3)[CH:4]=[CH:5][CH:10]=[CH:11][CH:12]=1