HCID 67387166, compound → HCID 67387912, compound
Reaction equation
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5]([O:14][CH:15]2[CH2:32][CH:31]3[N:17]([C:18](=[O:38])[N:19]([CH3:37])[CH2:20][CH2:21][CH2:22][CH2:23][CH:24]=[CH:25][CH:26]4[C:28]([C:34]([OH:36])=O)([NH:29][C:30]3=[O:33])[CH2:27]4)[CH2:16]2)=[N:4][CH:3]=1.ClC1N=C(OC2CC3N(C(=O)N(C)CCCCC=CC4C(C([NH:74][S:75]([CH:78]5[CH2:80][CH2:79]5)(=[O:77])=[O:76])=O)(NC3=O)C4)C2)C2C(C=1)=CC(OC)=CC=2>>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[C:5]([O:14][CH:15]2[CH2:32][CH:31]3[N:17]([C:18](=[O:38])[N:19]([CH3:37])[CH2:20][CH2:21][CH2:22][CH2:23][CH:24]=[CH:25][CH:26]4[C:28]([C:34]([NH:74][S:75]([CH:78]5[CH2:80][CH2:79]5)(=[O:77])=[O:76])=[O:36])([NH:29][C:30]3=[O:33])[CH2:27]4)[CH2:16]2)=[N:4][CH:3]=1Participants
Procedure
The title product 66 was prepared from 17-(4-bromo-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (65) following the same procedures described for the preparation of N-[17-(3-chloro-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo-[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide (43, Example 11): m/z=691 (M+H)+; 1H-NMR (CDCl3): 10.7 (br s, 1H), 8.09 (d, J=9.1 Hz, 1H), 7.3 (d, J=2.4 Hz, 1H), 7.25 (s, 1H), 7.15 (dd, J=9.1 Hz, 2.4, 1H), 7 (br s, 1H), 5.8 (br s, 1H), 5.74 (dd, J=18.2 Hz, 8, 1H), 5.16 (t, J=10.3 Hz, 1H), 4.74 (dd, J=9.3 Hz, 7, 1H), 4.05 (dd, J=11.1 Hz, 4, 1H), 3.95 (s, 3H), 3.6 (d, J=11.1 Hz, 1H), 3.1-3.2 (m, 1H), 2.9-3 (m, 1H), 2.83 (s, 3H), 2.4-2.5 (m, 3H), 2.19-2 (m, 2H), 2.5-2.7 (m, 4H), 1.4-1 (m, 3H), 1.2-1.35 (m, 2H), 1.05-1.15 (m, 1H), 0.95-1 (m, 1H).
Sources & evidence
- ORD record
- ord-35aaad09691d499f9a10dfc349de8f51
- Source dataset
- uspto-grants-2011_09
- Patent number
- US08012939B2
Reaction notes
Loading…