Reaction Steps
The title product 68 was prepared from 17-(3-pyrazol-1-yl-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (67) following the same procedures described for the preparation of N-[17-(3-chloro-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide (43, Example 11): m/z=678 (M+H)+; 1H-NMR (CDCl3): 10.5 (br s, 1H), 8.4 (dd, J=2.5 Hz, 0.5, 1H), 8 (d, J=9.8 Hz, 1H), 7.75 (s, 2H), 7.00-7.10 (m, 2H), 6.55 (s, 1H), 6.45 (dd, J=2.5 Hz, 0.5, 1H), 5.95 (br s, 1H), 5.75 (dd, J=18.1 Hz, 8 Hz, 1H), 5.1 (t, J=10.3 Hz, 1H), 4.75 (t, J=7.0 Hz, 1H), 4.1 (dd, J=11.0 Hz, 4.3, 1H), 3.90 (s, 3H), 3.70 (d, J=11.0 Hz, 1H), 3.10-3.20 (m, 1H), 2.90-3.01 (m, 1H), 2.85 (s, 3H), 2.50-2.62 (m, 3H), 2.20-2.30 (m, 1H), 1.90-2.00 (m, 2H), 1.55-1.60 (m, 4H), 1.30-1.50 (m, 6H).
