HRID905552

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCN(C)C(=O)N4C3)nc(Cl)cc2c1

HCID76674825

未命名化合物

HCID178487743

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(OC3CC4C(=O)NC5(C(=O)O)CC5C=CCCCCN(C)C(=O)N4C3)nc(-c3nc(C(C)C)cs3)cc2c1

HCID67387929

未命名化合物

PROCEDURE

实验过程

The title product 69 was prepared from 1-hydroxy-3-(4-isopropylthiazol-2-yl)-6-methoxyisoquinoline (6) following the same procedures described for the preparation of 17-(3-chloro-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (42, Example 10): m/z=634 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-294da2fff82d4f789cdb8e73273f5e10
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08012939B2
来源说明: uspto-grants-2011_09

反应 SMILES

[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([C:14]2[S:15][CH:16]=[C:17]([CH:19]([CH3:21])[CH3:20])[N:18]=2)[N:3]=1.ClC1N=C(O[CH:36]2[CH2:53][CH:52]3[N:38]([C:39](=[O:59])[N:40]([CH3:58])[CH2:41][CH2:42][CH2:43][CH2:44][CH:45]=[CH:46][CH:47]4[C:49]([C:55]([OH:57])=[O:56])([NH:50][C:51]3=[O:54])[CH2:48]4)[CH2:37]2)C2C(C=1)=CC(OC)=CC=2>>[CH:19]([C:17]1[N:18]=[C:14]([C:4]2[N:3]=[C:2]([O:1][CH:36]3[CH2:53][CH:52]4[N:38]([C:39](=[O:59])[N:40]([CH3:58])[CH2:41][CH2:42][CH2:43][CH2:44][CH:45]=[CH:46][CH:47]5[C:49]([C:55]([OH:57])=[O:56])([NH:50][C:51]4=[O:54])[CH2:48]5)[CH2:37]3)[C:11]3[C:6]([CH:5]=2)=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[S:15][CH:16]=1)([CH3:21])[CH3:20]