HCID 67387344, compound → HCID 67387468, compound

HRID 905556Notes

Reaction equation

HRID 905556 reaction equation
[Br:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[C:7]2[O:14][CH:15]1[CH2:33][CH:32]2[N:17]([C:18](=[O:38])[NH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]=[CH:26][CH:27]3[C:29]([C:35](O)=[O:36])([NH:30][C:31]2=[O:34])[CH2:28]3)[CH2:16]1.C1(C2N=C(C3N=C(OC4CC5C(C(=O)N(C)CCCCC=CC6C(C([NH:81][S:82]([CH:85]7[CH2:87][CH2:86]7)(=[O:84])=[O:83])=O)(NC5=O)C6)C4)C4C(C=3)=CC(OC)=CC=4)SC=2)CC1>>[Br:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[C:7]2[O:14][CH:15]1[CH2:33][CH:32]2[N:17]([C:18](=[O:38])[NH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH:25]=[CH:26][CH:27]3[C:29]([C:35]([NH:81][S:82]([CH:85]4[CH2:87][CH2:86]4)(=[O:84])=[O:83])=[O:36])([NH:30][C:31]2=[O:34])[CH2:28]3)[CH2:16]1

Participants

3

Reactant 2

HCID 67387344HCID 67387344, compoundHCID 67387571HCID 67387571, compound

Product 1

HCID 67387468HCID 67387468, compound

Procedure

The title compound was prepared from 18-[5-bromo-6-methoxyisoquinolin-1-yloxy]-2,15-dioxo-3,14,16-triazatricyclo[14.3.0.04,6]nonadec-7-ene-4-carboxylic acid (74) following the procedure reported for synthesis of N-[17-[3-(4-cyclopropylthiazol-2-yl)-6-methoxyisoquinolin-1-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]_octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide (30): m/z=691 (M+H)+.

Sources & evidence

ORD record
ord-25f5157371fd4cad8dec45d0a24e69cc
Source dataset
uspto-grants-2011_09
Patent number
US08012939B2

Reaction notes

Loading…