HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → 2-(3-Chloro-6-methoxy-[1,5]naphthyridin-4-yl)-acrylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 8-Bromo-7-chloro-2-methoxy-1,5-naphthyridine | HCID 51358223 | — |
| Product | 2-(3-Chloro-6-methoxy-[1,5]naphthyridin-4-yl)-acrylic acid ethyl ester | HCID 66897381 | — |
Reaction Steps
Starting from 8-bromo-7-chloro-2-methoxy-[1,5]naphthyridine (41.75 g, 152.6 mmol) and diethyl malonate (70.2 mL, 3 eq.), the title compound was obtained as a white solid (31.35 g, 107.2 mmol) using the procedures reported in WO 2007/071936 for the analogous methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012961B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-8456a730de8b4b6b9ab8c3ae34722679 |
| Source note | uspto-grants-2011_09 |