HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 905591Generated: October 26, 2026
Cyclopentylacetyl chloride → 2-Cyclopentyl-N-(2,6-difluoro-4-morpholin-4-yl-phenyl)-acetamide
https://huagongshe.com/reaction/905591
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclopentylacetyl chloride | HCID 3485182 | — |
| Reactant | 2,6-Difluoro-4-morpholin-4-yl-phenylamine | HCID 59244384 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Cyclopentyl-N-(2,6-difluoro-4-morpholin-4-yl-phenyl)-acetamide | HCID 11602255 | 75% |
Reaction Steps
2,6-Difluoro-4-morpholin-4-yl-phenylamine (0.20 g) and cyclopentylacetyl chloride (149 μL) were dissolved in acetonitrile (4 mL) and heated to 150° C. for 10 minutes in a sealed microwave process vial. The reaction mixture was concentrated in vacuo and purified by flash chromatography to furnish 228 mg (75%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08012962B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-d85462fd6d864d39a916dd2b5d889390 |
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| Source note | uspto-grants-2011_09 |
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