HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 905617Generated: October 30, 2026
2-Methoxyethylamine → 2-Butoxy-8-methoxy-9-{4-[(2-methoxyethyl)amino]butyl}-9H-purine-6-amine
https://huagongshe.com/reaction/905617
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 9-(4-Bromobutyl)-2-butoxy-8-methoxyadenine | HCID 23158511 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Butoxy-8-methoxy-9-{4-[(2-methoxyethyl)amino]butyl}-9H-purine-6-amine | HCID 23158549 | — |
Reaction Steps
The compound obtained in Example 2-13 step (i) (500 mg) and (2-methoxyethyl)amine (303 mg) were dissolved in acetonitrile (5 ml) and stirred at 80° C. for 1 hour. The reaction mixture was cooled, filtered and purified by RPHPLC to give the titled compound as a white solid. Yield: 270 mg (55%); mp 99-100° C., MS APCI+ve 367 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08012964B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-6bc259649b6c4e509eb5c62c3f69751b |
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| Source note | uspto-grants-2011_09 |
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