HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl [3-({[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl]amino}sulfonyl)phenyl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 9-(3-Aminopropyl)-2-butoxy-8-methoxy-9H-purin-6-amine | HCID 23158546 | — |
| Reactant | Methyl [3-(chlorosulfonyl)phenyl]acetate | HCID 23388821 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl [3-({[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl]amino}sulfonyl)phenyl]acetate | HCID 11576824 | — |
Reaction Steps
The compound obtained in Example 2-3 step (ii) (240 mg), triethylamine (0.12 ml) and methyl [3-(chlorosulfonyl)phenyl]acetate (204 mg) were dissolved in acetonitrile (5 ml), and the same manner to Example 2-13 step (iii) was conducted to give the titled compound as a white solid. Yield: 35 mg (9%); mp 218-219° C., MS APCI+ve 493 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012964B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-66d8b2570dee463ca052ef25be34dd45 |
| Source note | uspto-grants-2011_09 |