HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Benzenamine, 4-[4-(1-piperidinyl)butyl]-, hydrochloride (1:2)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 4-(4-Nitrophenyl)butyric acid | HCID 79711 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzenamine, 4-[4-(1-piperidinyl)butyl]-, hydrochloride (1:2) | HCID 68001600 | — |
Reaction Steps
4-(4-nitrophenyl)butanoic acid and piperidine were allowed to undergo the reaction in DMF using WSC hydrochloride and HOBt, subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to reduce the nitro group, and then reduced in the same manner as in Reference Example 2, and the resulting compound was subjected to salt formation using 4 M hydrogen chloride/ethyl acetate solution to obtain 4-(4-piperidin-1-ylbutyl) aniline dihydrochloride. F: 233.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012959B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-f30be38d428d48409a69508d4068b516 |
| Source note | uspto-grants-2011_09 |