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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 905656Generated: October 28, 2026

2-Fluoro-4-nitrotoluene → 2-(4-Amino-2-fluorophenyl)ethanol

https://huagongshe.com/reaction/905656

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-4-nitrotolueneHCID 74025—
ReactantSodium MethoxideHCID 10942334—
SolventDimethyl SulfoxideHCID 679—
Product2-(4-Amino-2-fluorophenyl)ethanolHCID 45090600—

Reaction Steps

2-Fluoro-4-nitrotoluene and p-formaldehyde were allowed to undergo the reaction in DMSO in the presence of sodium methoxide, and then the resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain 3-fluoro-4-(2-hydroxyethyl)aniline. F: 156.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08012959B2
Source datasetuspto-grants-2011_09
ORD IDord-086472b3a0ed488ab810fd3950878be7
Source noteuspto-grants-2011_09