Nitric Acid → HCID 67389001, compound

HRID 905663Notes

Reaction equation

HRID 905663 reaction equation
C1([C@H]2NC(=O)COC2)C=CC=CC=1.[N+]([O-])(O)=O.[N+:18]([C:21]1[CH:26]=[CH:25][C:24]([C@H:27]2[NH:32][C:31](=[O:33])[CH2:30][O:29][CH2:28]2)=[CH:23][CH:22]=1)([O-])=O>S(=O)(=O)(O)O>[NH2:18][C:21]1[CH:22]=[CH:23][C:24]([C@H:27]2[NH:32][C:31](=[O:33])[CH2:30][O:29][CH2:28]2)=[CH:25][CH:26]=1

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 44195698(5R)-5-Phenylmorpholin-3-oneHCID 67388771HCID 67388771, compound

Product 1

HCID 67389001HCID 67389001, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

(R)-5-phenylmorpholin-3-one was allowed to react with nitric acid in concentrated sulfuric acid, and the resulting (R)-5-(4-nitrophenyl)morpholin-3-one (F: 223) was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain (R)-5-(4-aminophenyl)morpholin-3-one. F: 193.

Sources & evidence

ORD record
ord-a73f98290d5e4b8da75405a2c85a356d
Source dataset
uspto-grants-2011_09
Patent number
US08012959B2

Reaction notes

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