HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 67388354, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-3-Bromopropylphthalimide | HCID 21611 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Trimethylsilyl isocyanate | HCID 70696 | — |
| Reactant | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 67388354 | HCID 67388354 | — |
Reaction Steps
1-(4-Nitrophenyl)piperazine and N-(3-bromopropyl)phthalimide were allowed to undergo the reaction under heating in 1-methyl-2-pyrrolidone in the presence of potassium carbonate. The resulting compound was allowed to react with hydrazine monohydrate in THF. The resulting compound was allowed to react with trimethylsilyl isocyanate in THF and then subjected to catalytic hydrogenation in the same manner as in Reference Example 3 to obtain {3-[4-(4-aminophenyl)piperazin-1-yl]propyl}urea. F: 276.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012959B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-838dd5df9d3847d08b56a0c2234703bc |
| Source note | uspto-grants-2011_09 |