HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Morpholin-4-yl-3-(2-morpholin-4-ylethoxy)aniline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(2-Chloroethyl)morpholine | HCID 76727 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | 2-Morpholin-4-yl-5-nitrophenol | HCID 23071565 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Morpholin-4-yl-3-(2-morpholin-4-ylethoxy)aniline hydrochloride | HCID 69279246 | — |
Reaction Steps
2-Morpholin-4-yl-5-nitrophenol and 4-(2-chloroethyl)morpholine were allowed to undergo the reaction in DMF in the presence of potassium carbonate, and then the resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 and further treated with 4 M hydrogen chloride/ethyl acetate solution in ethyl acetate to obtain 4-morpholin-4-yl-3-(2-morpholin-4-ylethoxy) aniline hydrochloride. F: 308.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012959B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-5a43a32d12de4e7594b8a9307ae9e636 |
| Source note | uspto-grants-2011_09 |