HCID 21431978, compound → (2-methoxy-5-methylphenyl)methanamine

HRID 905673Notes

Reaction equation

HRID 905673 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:4]=1[C:5]([NH2:7])=O.Cl.C(OCC)(=O)C>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][C:4]=1[CH2:5][NH2:7]

Participants

3

Reactant 2

HCID 21431978HCID 21431978, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 17835276(2-methoxy-5-methylphenyl)methanamine

Procedure

2-Methoxy-5-methylbenzamide was treated in the same manner as the reduction shown in Reference Example 2 and further treated with 4 M hydrogen chloride/ethyl acetate solution to obtain 2-methoxy-5-methylbenzylamine. F: 152.

Sources & evidence

ORD record
ord-963bfa98cf064c23b67141b9cc9570d2
Source dataset
uspto-grants-2011_09
Patent number
US08012959B2

Reaction notes

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