HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → [3-(Aminomethyl)-4-fluorophenyl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | 2-Fluoro-5-formylbenzonitrile | HCID 2769582 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [3-(Aminomethyl)-4-fluorophenyl]methanol | HCID 23071542 | — |
Reaction Steps
2-Fluoro-5-formylbenzonitrile was treated with sodium borohydride and dimethyl sulfate in THF to obtain 5-hydroxymethyl-2-fluorobenzylamine. F: 156.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012959B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-f1e709b0249d4fa68a4188e3e371c418 |
| Source note | uspto-grants-2011_09 |