2-(Methylamino)ethanol → 3-(N-2-hydroxyethyl-N-methylamino)benzonitrile

HRID 905676Notes

Reaction equation

HRID 905676 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].[CH3:10][NH:11][CH2:12][CH2:13][OH:14]>>[OH:14][CH2:13][CH2:12][N:11]([C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6])[CH3:10]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 678803-Fluorobenzonitrile

Product 1

HCID 586560573-(N-2-hydroxyethyl-N-methylamino)benzonitrile

Procedure

By treating 3-fluorobenzonitrile with N-methylethanolamine under heating, 3-(N-2-hydroxyethyl-N-methylamino)benzonitrile was obtained (F: 177). This benzonitrile was treated in the same manner as in Reference Example 2 to obtain 3-(N-2-hydroxyethyl-N-methylamino)benzylamine. F: 181.

Workup

  1. temperatureunder heating

Sources & evidence

ORD record
ord-e9398615bae447e192c2c88918760009
Source dataset
uspto-grants-2011_09
Patent number
US08012959B2

Reaction notes

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