HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → N-(5-fluoro-2-oxo-2,3-dihydro-1H-indol-7-yl)-formamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-(6-Amino-5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-diethylamino-ethyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one | HCID 66607288 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(5-fluoro-2-oxo-2,3-dihydro-1H-indol-7-yl)-formamide | HCID 59250102 | 99% |
Reaction Steps
A solution of acetic anhydride (1.6 ml) and formic acid (1.2 ml) was stirred for 1 hour at room temperature, and added with 6-amino-5-fluoro-1,3-dihydro-indol-2-one (4.0 g, 24 mmol) obtained from Example 7 in 60 ml of tetrahydrofuran and piperidine (0.04 ml). Upon the completion of the addition, the mixture was stirred for 3 hours at room temperature until a precipitate was formed. The solid was filtered and recrystallized from methanol to give N-(5-fluoro-2-oxo-2,3-dihydro-1H-indol-7-yl)-formamide (4.6 g, 99%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012966B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-9fe1c852300a41edaf961e09e748893b |
| Source note | uspto-grants-2011_09 |