Malic Acid → HCID 66607315, compound

HRID 905887Notes

Reaction equation

HRID 905887 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[CH:12][C:13]1[NH:21][C:20]2[CH2:19][CH2:18][N:17]([CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[C:16](=[O:30])[C:15]=2[C:14]=1[CH3:31].[OH:32][CH:33]([CH2:37][C:38]([OH:40])=[O:39])[C:34]([OH:36])=[O:35]>>[C:34]([OH:36])(=[O:35])[CH:33]([CH2:37][C:38]([OH:40])=[O:39])[OH:32].[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[CH:12][C:13]1[NH:21][C:20]2[CH2:19][CH2:18][N:17]([CH2:22][CH2:23][N:24]3[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)[C:16](=[O:30])[C:15]=2[C:14]=1[CH3:31]

Participants

3

Reactant 2

HCID 525Malic AcidHCID 66607316HCID 66607316, compound

Product 1

HCID 66607315HCID 66607315, compoundYield 95%

Procedure

The title compound was prepared under the same conditions described in Example 132 with 2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-morpholin-4-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one and 2-hydroxyl-succinic acid as starting materials to give 2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-morpholin-4-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one malate (20 g, 95%) as a yellow solid.

Workup

  1. customThe title compound was prepared under the same conditions

Sources & evidence

ORD record
ord-540593697fb54d118dc57d98eeb2ba4f
Source dataset
uspto-grants-2011_09
Patent number
US08012966B2

Reaction notes

Loading…