Alanine methyl ester hydrochloride → HCID 54712169, compound

Participants

Reaction Conditions

Reaction Steps

In a 35 mL sealed vial under N2 was suspended methyl 4-hydroxy-8-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (0.50 g, 1.9 mmol) in 1,4-dioxane (15 mL). To this solution was added L-alanine methyl ester hydrochloride (0.29 g, 2.1 mmol) and the reaction mixture was stirred at 120° C. overnight (18 h). The solution was removed from the heat and filtered over a fine frit funnel to remove any undissolved starting material. The filtrate was concentrated in vacuo and the remaining precipitate was suspended in Et2O, filtered and washed with Et2O and dried to provide a light yellow solid. Yield=0.40 g, 63%.

Provenance & Evidence