HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 905913Generated: October 29, 2026
Hydrochloric Acid → 2-(7-(3,5-Dimethylisoxazol-4-yl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid
https://huagongshe.com/reaction/905913
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 59340101 | HCID 59340101 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(7-(3,5-Dimethylisoxazol-4-yl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid | HCID 59340082 | — |
Reaction Steps
Suspended Methyl 2-(7-(3,5-dimethylisoxazol-4-yl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate in 3 ml MeOH, 1 ml THF, and 2 ml 1M aqueous NaOH and stirred at 24° C. for 4 hours. The mixture was acidified to pH=1 using 2M aqueous HCl and the solids collected by filtration, washed with H2O and dried in vacuo: 50 mg white solids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08012968B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-e4a622557bd04275aa19cc25c115fb90 |
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| Source note | uspto-grants-2011_09 |
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