Lithium hydroxide, monohydrate → HCID 54712199, compound

Participants

Reaction Steps

Methyl 3-((2-(benzyloxy)-2-oxoethyl)carbamoyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-7-carboxylate (26 mg, 61 μmol) (65689-17-3) was dissolved in 12 ml dioxane/H2O (5:1) and to this was added lithium hydroxide monohydrate (613 μl, 613 μmol) as a 1M aqueous solution. The resultant mixture was heated to 60 C for 4 hrs. The solvent was removed in vacuo and the aqueous layer was acidified with 2N HCl to pH2. Following dilution with EtOAc, the layers were separated and the aqueous layer was extracted with EtOAc (3×). The organic layer was washed with H2O and brine, then dried over Na2SO4. The solvent was removed by rotovap, azeotroping with benzene (3×) to give a light yellow solid which was rinsed with DCM followed by MeOH.

Provenance & Evidence