HCID 59363373, compound → HCID 96581950, compound

HRID 905933Notes

Reaction equation

HRID 905933 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7](=O)[CH:6]([CH3:11])[CH2:5]1)(=[O:3])[CH3:2].Cl.C[C@H]1[C@@H]([NH2:20])CCOC1>>[NH2:20][C@H:7]1[CH2:8][CH2:9][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][C@H:6]1[CH3:11]

Participants

3

Reactant 2

HCID 59363373HCID 59363373, compoundHCID 126970408(3S,4S)-3-Methyltetrahydro-2H-pyran-4-amine hydrochloride

Product 1

HCID 96581950HCID 96581950, compound

Procedure

Racemic cis 1-(4-amino-3-methyl-piperidin-1-yl)-ethanone was prepared in the same manner from racemic 1-acetyl-3-methyl-piperidin-4-one. In this instance, 1 atm H2 was used instead of 55 psi, and the HCl treatment was omitted.

Sources & evidence

ORD record
ord-0695cc4bbd8e4b328664cb17c9f0b3c7
Source dataset
uspto-grants-2011_09
Patent number
US08012974B2

Reaction notes

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