Benzylamine → Racemic cis 1-(4-benzylamino-3-methyl-piperidin-1-yl)-ethanone

HRID 905937Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][C:7](=O)[CH:6]([CH3:11])[CH2:5]1)(=[O:3])[CH3:2].[CH2:12]([NH2:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([NH:19][C@H:7]1[CH2:8][CH2:9][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][C@H:6]1[CH3:11])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 59363373HCID 59363373, compound

Product 1

HCID 131729152Racemic cis 1-(4-benzylamino-3-methyl-piperidin-1-yl)-ethanone

Procedure

Racemic cis 1-(4-benzylamino-3-methyl-piperidin-1-yl)-ethanone was prepared in the same manner from racemic 1-acetyl-3-methyl-piperidin-4-one. In this instance, benzylamine was used instead of (R)-1-phenylethylamine.

Sources & evidence

ORD record: ord-3f63f6d30720425085e2315bc106308a
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08012974B2

Reaction notes

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