Benzylamine → Racemic cis benzyl-(1-methanesulfonyl-3-methyl-piperidin-4-yl)-amine

HRID 905938Notes

Reaction equation

[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][C:8](=O)[CH:7]([CH3:12])[CH2:6]1)(=[O:4])=[O:3].[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([NH:20][C@H:8]1[CH2:9][CH2:10][N:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:6][C@H:7]1[CH3:12])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 67386424Racemic 1-methanesulfonyl-3-methyl-piperidin-4-one

Product 1

HCID 131729153Racemic cis benzyl-(1-methanesulfonyl-3-methyl-piperidin-4-yl)-amine

Procedure

Racemic cis benzyl-(1-methanesulfonyl-3-methyl-piperidin-4-yl)-amine was prepared in the same manner from racemic 1-methanesulfonyl-3-methyl-piperidin-4-one. In this instance, benzylamine was used instead of (R)-1-phenylethylamine.

Sources & evidence

ORD record: ord-bcf661b984c941d1808683aac2a263b1
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08012974B2

Reaction notes

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