HCID 51354609, compound → HCID 25068200, compound

Participants

Reaction Steps

To ((3R,5R)-1-benzyl-5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester (prepared as described in WO2004014893) (4.6 g, 15.11 mmol) Pd(OH)2 on carbon (0.46 g) and EtOH (80 mL) were added and the reaction mixture stirred at RT under 1 atm of H2. After 3 hours the palladium was filtered off and the solvent was evaporated. The remaining oil was dried under high vacuum to give 2.9 g of ((3R,5R)-5-methyl-piperidin-3-yl)-carbamic acid tert-butyl ester as an off-white crystalline solid (89% yield).

Provenance & Evidence