HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 59401601, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | rel-1,1-Dimethylethyl N-[(1R,3R)-3-(hydroxymethyl)cyclohexyl]carbamate | HCID 90307591 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 59401601 | HCID 59401601 | 128.2% |
Reaction Steps
Racemic trans 3-hydroxymethyl-cyclohexyl-carbamic acid tert-butyl ester (0.9 g, 3.925 mmol) was dissolved in DCM and 4M HCl in dioxane (9.8 mL) was added. The resulting mixture was stirred at RT for 4 hours before being evaporated. The residue was dried under high vacuum to give 0.65 g of crude racemic trans-3-amino-cyclohexyl-methanol as white foam (>95% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012974B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-84ca0cf3d10d4f4fba6c33e732b8a703 |
| Source note | uspto-grants-2011_09 |