Dichloromethane → 3-Methyl-piperidin-4-one hydrochloride

HRID 905963Notes

Reaction equation

HRID 905963 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[O:14])[CH:10]([CH3:15])[CH2:9]1)=O)(C)(C)C.C(Cl)[Cl:17]>>[ClH:17].[CH3:15][CH:10]1[C:11](=[O:14])[CH2:12][CH2:13][NH:8][CH2:9]1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 22644642tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Product 1

HCID 227288643-Methyl-piperidin-4-one hydrochloride

Conditions

Temperature
25 °C

Procedure

To a solution of racemic 3-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester in anhydrous DCM at 0° C., ethanolic-HCl was added slowly and the reaction mixture was allowed to stir at 25° C. for 3 h. TLC (hexanes/EtOAc 40% EtOAc) showed complete consumption of the starting material. The reaction mixture was evaporated to give racemic 3-methyl-piperidin-4-one hydrochloride which was used crude in the next reaction.

Workup

  1. customconsumption of the starting material
  2. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-2a0c0842c3c64a78a2bcff4361596662
Source dataset
uspto-grants-2011_09
Patent number
US08012974B2

Reaction notes

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