反应详情

温度

0 °C

Acetyl chloride (3.5 mL, 49.3 mmol) was added dropwise at 0° C. to 100 mL of MeOH. The resulting mixture was stirred at 0° C. for 5 minutes before adding (1S,3S)-3-tert-butoxycarbonylamino-cyclopentanecarboxylic acid methyl ester (1.192 g, 5.2 mmol). The reaction mixture was allowed to warm up to RT and stirred for 48 h before being evaporated to give crude (1S,3S)-3-amino-cyclopentanecarboxylic acid methyl ester hydrochloride which was used as is in the following step.

1. temperatureto warm up to RT
2. stirringstirred for 48 h
3. custombefore being evaporated