HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 905982Generated: October 29, 2026
Thiourea → 2-(1-Trifluoromethyl-cyclopropylmethyl)-isothiourea p-toluenesulfonic acid salt
https://huagongshe.com/reaction/905982
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | HCID 24805800 | HCID 24805800 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(1-Trifluoromethyl-cyclopropylmethyl)-isothiourea p-toluenesulfonic acid salt | HCID 86642302 | 99.3% |
Reaction Steps
A mixture of toluene-4-sulfonic acid 1-trifluoromethyl-cyclopropylmethyl ester (2 g, 6.796 mmol) and thiourea (0.52 g, 6.831 mmol) in 5 mL of EtOH was stirred at 90° C. for 3 hours before being cooled to RT and evaporated to give 2.5 g of 2-(1-trifluoromethyl-cyclopropylmethyl)-isothiourea p-toluenesulfonic acid salt (>95% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08012974B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-1a72a4b9c9114a05ac9942457f506dcf |
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| Source note | uspto-grants-2011_09 |
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