Cyclohexyl isocyanate → HCID 67385884, compound

Participants

Reaction Steps

7-Methyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine (41 mg, 0.147 mmol) was dissolved in 1,2-dichloroethane (1.5 mL). Cyclohexylisocyanate (0.19 mL, 1.47 mmol) was added and the reaction mixture was heated to reflux for 64 hr, cooled to RT, concentrated, purified by SiO2 chromatography (8 g SiO2, hexanes/EtOAc 0-50% EtOAc) to give 38 mg of 1-cyclohexyl-3-[7-methyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea as a white solid (64% yield).

Provenance & Evidence