Ethylenediamine → HCID 46233739, compound

Participants

Reaction Conditions

Reaction Steps

1-Cyclohexyl-3-[7-methyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea (38 mg, 0.094 mmol) was dissolved in a solution of HCl in AcOH (1M, 1.9 mL), and heated at 50° C. in the sealed tube overnight. The reaction mixture was concentrated to dryness, dissolved in 1 mL of MeOH:H2O:Et3N 8:1:1 and ethylenediamine (63 ul, 0.94 mmol) was added. The reaction mixture was stirred overnight, concentrated and purified by SiO2 chromatography (8 g SiO2, DCM/MeOH 0-5% MeOH) to give 7 mg of 1-cyclohexyl-3-(7-methyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)-urea as a white solid (27% yield).

Provenance & Evidence