Hydroxyamine hydrochloride → HCID 67385653, compound

Participants

Reaction Steps

Benzhydrylidene-[7-chloro-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-amine (992 mg, 2.14 mmol), NaOAc (421 mg, 5.14 mmol) and NH2OH HCl (268 mg, 3.85 mmol) were dissolved in MeOH (21 mL) and stirred at RT overnight, and partitioned between EtOAc and H2O. The organic layer was dried (MgSO4), filtered, concentrated, and purified by SiO2 chromatography (150 g SiO2, hexanes/EtOAc 0 to 50% EtOAc) to give 202 mg of 7-chloro-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine as a white solid (32% yield).

Provenance & Evidence