Cyclohexyl isocyanate → HCID 67385304, compound

Participants

Reaction Steps

7-Chloro-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine (100 mg, 0.335 mmol) was dissolved in 1,2-dichloroethane (3.4 mL). Cyclohexylisocyanate (0.43 mL, 3.35 mmol) was added and the reaction mixture was heated to reflux overnight, cooled to RT, and concentrated. The residue was dispersed in 3 mL of toluene, cyclohexylisocyanate (0.86 mL, 6.70 mmol) was added and the reaction mixture was heated to reflux overnight, and cooled to 0° C. The precipitates were filtered, washed with toluene and dried under high vacuum to give 44 mg of 1-cyclohexyl-3-[7-chloro-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea as a white solid (31% yield).

Provenance & Evidence