Ethylenediamine → HCID 46234567, compound

Participants

Reaction Conditions

Reaction Steps

1-Cyclohexyl-3-[7-chloro-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea (44 mg, 0.104 mmol) was dissolved in a solution of HCl in AcOH (1M, 2.1 mL), and heated at 50° C. in the sealed tube overnight. The reaction mixture was concentrated to dryness, dissolved in 1 mL of MeOH:H2O:Et3N 8:1:1 and ethylenediamine (69 ul, 1.04 mmol) was added. The reaction mixture was stirred for 5 days, concentrated and purified by SiO2 chromatography (8 g SiO2, DCM/MeOH 0 to 10% MeOH) to give 5 mg of 1-cyclohexyl-3-(7-chloro-5H-pyrrolo[2,3-b]pyrazin-2-yl)-urea as a white solid (16% yield).

Provenance & Evidence