HCID 67385909, compound → HCID 67386141, compound

Participants

Reaction Steps

A mixture of (3R,5R)-3-methyl-5-{3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-ureido}-piperidine-1-carboxylic acid benzyl ester (1.04 g, 1.93 mmol) and palladium hydroxide 20% on carbon (0.15 g) in 20 mL of EtOH was stirred at RT under hydrogen (1 atm) for 2 hours before being filtered. The dark brown filtrate was evaporated to give 0.76 g of 1-((3R,5R)-5-methyl-piperidin-3-yl)-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea (>95%).

Provenance & Evidence