1-Propanesulfonyl chloride, 2-methyl- → HCID 67385096, compound

HRID 906025Notes

Reaction equation

HRID 906025 reaction equation
Cl.Cl.[NH:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:10]([NH:12][C:13]1[N:14]=[C:15]2[CH:21]=[CH:20][N:19]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[C:16]2=[N:17][CH:18]=1)=[O:11].[CH3:30][CH:31]([CH3:37])[CH2:32][S:33](Cl)(=[O:35])=[O:34]>>[CH3:30][CH:31]([CH3:37])[CH2:32][S:33]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:10]([NH:12][C:13]1[N:14]=[C:15]2[CH:21]=[CH:20][N:19]([CH2:22][O:23][CH2:24][CH2:25][Si:26]([CH3:29])([CH3:28])[CH3:27])[C:16]2=[N:17][CH:18]=1)=[O:11])(=[O:35])=[O:34]

Participants

3

Reactant 2

HCID 1822361-Propanesulfonyl chloride, 2-methyl-HCID 67385793HCID 67385793, compound

Product 1

HCID 67385096HCID 67385096, compound

Procedure

Racemic 1-[1-(2-methyl-propane-1-sulfonyl)-pyrrolidin-2-ylmethyl]-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea was prepared in the same manner from 1-pyrrolidin-2-ylmethyl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea dihydrochloride and 2-methyl-propane-1-sulfonyl chloride.

Sources & evidence

ORD record
ord-ef57f713be0446c19f339916a1a2053e
Source dataset
uspto-grants-2011_09
Patent number
US08012974B2

Reaction notes

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