Methanesulfonyl chloride → HCID 67385578, compound

HRID 906026Notes

Reaction equation

Cl.Cl.[NH:3]1[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([NH:10][C:11]([NH:13][C:14]2[N:15]=[C:16]3[CH:22]=[CH:21][N:20]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[C:17]3=[N:18][CH:19]=2)=[O:12])[CH2:4]1.[CH3:31][S:32](Cl)(=[O:34])=[O:33]>>[CH3:31][S:32]([N:3]1[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([NH:10][C:11]([NH:13][C:14]2[N:15]=[C:16]3[CH:22]=[CH:21][N:20]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[C:17]3=[N:18][CH:19]=2)=[O:12])[CH2:4]1)(=[O:34])=[O:33]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 67385495HCID 67385495, compound

Product 1

HCID 67385578HCID 67385578, compound

Procedure

Racemic 1-(1-methanesulfonyl-azepan-3-yl)-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea was prepared in the same manner from racemic 1-azepan-3-yl-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea dihydrochloride and methanesulfonyl chloride.

Sources & evidence

ORD record: ord-b9cc2302c4634f2699f7399edbbe6e0b
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08012974B2

Reaction notes

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