Water → HCID 59363383, compound

Participants

Reaction Conditions

Reaction Steps

1-[(S)-1-(2,2-Dimethyl-propane-1-sulfonyl)-piperidin-3-yl]-3-[5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea (0.045 g, 0.086 mmol) was dissolved in 1M HCl in acetic acid (0.9 mL) and stirred at 60° C. After 1.5 hours the solvent was evaporated and the residue was dried under high vacuum. The remaining oil was taken up in MeOH:H2O:EtN 8:1:1 (0.9 mL) and ethylenediamine (0.029 mL, 0.429 mmol) was added. The yellow solution stirred at RT overnight. The solvent was evaporated and the residue was purified by SiO2 chromatography (8 g SiO2, DCM:MeOH 0 to 5% MeOH) to give 0.025 g of 1-[(S)-1-(2,2-dimethyl-propane-1-sulfonyl)-piperidin-3-yl]-3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-urea as an off-white solid (74% yield).

Provenance & Evidence