HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → HCID 2838541, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 4-Bromobenzoic acid | HCID 11464 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 2838541 | HCID 2838541 | 73% |
Reaction Steps
To a solution of 4-bromobenzoic acid in DMF (0.10 M), 3 eq of NMM, 1.5 eq of Py-BOP and 1.1 eq of 4-aminophenol were added and the mixture was stirred at RT for 20 min. DMF was concentrated in vacuo and the residue diluted with EtOAc and aqueous HCl (1N). The resultant precipitate was filtered off and dried in vacuo to afford the title compound (73%); MS (ES+) m/z 292 (M+H)+, m/z 294 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012982B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-e9c6648ade194df1b4247a6358f61683 |
| Source note | uspto-grants-2011_09 |