HCID 67401930, compound → 183324-68-7

Participants

Reaction Steps

A solution of methyl 7-methyl-1-benzofuran-6-carboxylate (370 mg, 1.95 mmol) in 35% aqueous potassium hydroxide/methanol (1:3, 4 mL) was stirred at reflux for 30 minutes. The methanol was removed under reduced pressure and resultant aqueous portion was brought to pH 2 using 6N aqueous hydrochloric acid. The precipitate which formed was collected by filtration and dried in vacuo to afford (258 mg, 75%) of 7-methyl-1-benzofuran-6-carboxylic acid. 1H NMR (400 MHz, DMSO-d6): 8.17 (d, 1H), 7.78 (d, 1H), 7.54 (d, 1H), 7.03 (d, 1H), 2.72 (s, 3H). MS (EI) for C10H8O3: 177 (MH+).

Provenance & Evidence