Lithium Hydroxide → HCID 53692096, compound

Participants

Reaction Conditions

Reaction Steps

To methyl 2-methyl-3-(methylamino)benzoate (125 mg, 0.698 mmol) in methanol (7 ml) was added 2M aqueous lithium hydroxide (1.8 ml, 3.63 mmol), and the solution was stirred at 25° C. for 3 h, at which point the volume was reduced by rotary evaporation. The aqueous mixture was diluted with water (3 ml) and the pH adjusted to 5 with 1 N hydrochloric acid. The resultant precipitate was collected by filtration and dried in vacuo to afford (50 mg, 42%) of 2-methyl-3-(methylamino)benzoic acid. MS (EI) for C9H11NO2: 166 (MH+).

Provenance & Evidence