Phenol → 4-(Aminocarbonyl)-2-methyl-5-(methyloxy)benzoic acid

Participants

Reaction Steps

Synthesized according to the method of reagent preparation 41 by replacement of step 6 with the conversion of methyl 4-cyano-5-iodo-2-methylbenzoate to methyl 4-cyano-5-hydroxy-2-methylbenzoate according to the method described in Chemical & Pharmaceutical Bulletin (2007), 55(9), 1361-1364 followed by phenol alkylation with iodomethane then proceeding with steps 7 and 8. 1H NMR (400 MHz, DMSO-d6): 7.69 (b, 1H), 7.63 (b, 2H), 7.45 (s, 1H), 3.88 (s, 3H), 2.44 (s, 3H); MS (EI) for C10H11NO4: 210 (MH+).

Provenance & Evidence