HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 4-(Aminocarbonyl)-2-methyl-5-{[2-(methyloxy)ethyl]oxy}benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | Methyl 4-cyano-5-iodo-2-methylbenzoate | HCID 67402433 | — |
| Reactant | Methyl 4-cyano-5-hydroxy-2-methylbenzoate | HCID 67404603 | — |
| Product | 4-(Aminocarbonyl)-2-methyl-5-{[2-(methyloxy)ethyl]oxy}benzoic acid | HCID 57748642 | — |
Reaction Steps
Synthesized according to the method of reagent preparation 41 by replacement of step 6 with the conversion of methyl 4-cyano-5-iodo-2-methylbenzoate to methyl 4-cyano-5-hydroxy-2-methylbenzoate according to the method described in Chemical & Pharmaceutical Bulletin (2007), 55(9), 1361-1364 followed by phenol alkylation with 2-bromoethyl methyl ether then proceeding with steps 7 and 8. MS (EI) for C12H15NO5: 254 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012956B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-59b355b37d4b49a4ababb0d816184777 |
| Source note | uspto-grants-2011_09 |