反应详情

Synthesized according to the method of reagent preparation 46 by first conducting step 2 to give a mixture of ethyl 3-bromo-2-chloro-4-cyanobenzoate and ethyl 5-bromo-2-chloro-4-cyanobenzoate then proceeding with step 1 using 1-cyclopropylethylamine followed by steps 3 and 4. 1HNMR (400 MHz, CD3OD): 7.49 (d, 1H), 7.22 (d, 1H), 2.84 (q, 2H), 1.17 (d, 3H), 0.9-0.76 (m, 1H), 0.3-0.26 (m, 2H), 0.04-0.00 (m, 2H). MS (EI) for C13H15ClN2O3: 284 (MH+).

1. customSynthesized
2. customaccording to the method of reagent preparation 46
3. customto give