8-Boc-3,8-diaza-bicyclo(3.2.1)octane → 4-(8-Isopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)aniline

HRID 906212Notes

Reaction equation

HRID 906212 reaction equation
[CH:1]([N:4]1[CH2:9][C@@H:8]2[CH2:10][C@H:5]1[CH2:6][N:7]2[C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)([CH3:3])[CH3:2].[C:18](OC(N1C2CCC1CNC2)=O)(C)(C)C>>[CH:1]([N:4]1[CH:5]2[CH2:10][CH2:18][CH:9]1[CH2:8][N:7]([C:11]1[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=1)[CH2:6]2)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 157409088-Boc-3,8-diaza-bicyclo(3.2.1)octaneHCID 579639114-((1S,4S)-5-Isopropyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-phenylamine

Product 1

HCID 579639154-(8-Isopropyl-3,8-diazabicyclo[3.2.1]octan-3-yl)aniline

Procedure

This compound is prepared according to the same procedure as described for Intermediate 7 using 8-(tert-butoxycarbonyl)-3,8-diazabicyclo[3.2.1]octane (J. Med.Chem., 1998, 41, 674-681).

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-1777f3b6f18b4f9d9f9923fadd392345
Source dataset
uspto-grants-2011_09
Patent number
US08012983B2

Reaction notes

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