2-Chloro-5-nitropyridine → 6-((1S,4S)-5-isopropyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-amine

HRID 906213Notes

Reaction equation

HRID 906213 reaction equation
[CH:1]([N:4]1[CH2:9][C@@H:8]2[CH2:10][C@H:5]1[CH2:6][N:7]2[C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13]C=1)([CH3:3])[CH3:2].ClC1C=CC([N+]([O-])=O)=C[N:20]=1>>[CH:1]([N:4]1[CH2:9][C@@H:8]2[CH2:10][C@H:5]1[CH2:6][N:7]2[C:11]1[N:20]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 783082-Chloro-5-nitropyridineHCID 579639114-((1S,4S)-5-Isopropyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-phenylamine

Product 1

HCID 673901786-((1S,4S)-5-isopropyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)pyridin-3-amine

Procedure

This compound is prepared according to the same procedure as described for Intermediate 7 using 2-chloro-5-nitropyridine.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-0c16f95ae55d40f490f6b03090a4d2db
Source dataset
uspto-grants-2011_09
Patent number
US08012983B2

Reaction notes

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