Methyl iodide → 2-Methylsulfanyl-1,4,5,6-tetrahydropyrimidin-3-ium iodide

Participants

Reaction Steps

The reaction mixture comprising one equivalent of 3,4,5,6-tetrahydro(1H)pyrimidine-2-thione and 1.2 equivalents of iodomethane in methanol (10 ml/g of thio-urea) is heated under reflux for 5 hours. After cooling down, the methanol is evaporated off under reduced pressure in order to quantitatively produce the product. The precipitate can then be washed in acetone or petroleum ether.

Provenance & Evidence