HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-Methyl-4-(6-trifluoromethyl-pyridin-3-yl)-1h-pyrimidin-2-one | HCID 67393593 | — |
| Product | 2-Chloro-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine | HCID 86624634 | — |
Reaction Steps
The title compound was prepared from 6-methyl-4-(6-trifluoromethyl-pyridin-3-yl)-1H-pyrimidin-2-one (2.0 g, 7.84 mmol) and phosphoroxychloride (12 ml) according to the general procedure I. Obtained as an orange solid (1.33 g, 62%). MS (ISP) 274.1 [(M+H)+]; mp 123.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012986B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-18fc520a46a74de5a98e88cc7640ff68 |
| Source note | uspto-grants-2011_09 |