2-Chloro-4-difluoromethyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine → 2-(4-Iodo-imidazol-1-yl)-4-difluoromethyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine

HRID 906255Notes

Reaction equation

HRID 906255 reaction equation
Cl[C:2]1[N:7]=[C:6]([CH:8]([F:10])[F:9])[CH:5]=[C:4]([C:11]2[CH:12]=[N:13][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:16]=2)[N:3]=1.[I:21][C:22]1[N:23]=[CH:24][NH:25][CH:26]=1>>[F:9][CH:8]([F:10])[C:6]1[CH:5]=[C:4]([C:11]2[CH:12]=[N:13][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:16]=2)[N:3]=[C:2]([N:25]2[CH:26]=[C:22]([I:21])[N:23]=[CH:24]2)[N:7]=1

Participants

3

Reactant 2

HCID 866246322-Chloro-4-difluoromethyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidineHCID 178506559HCID 178506559, compound

Product 1

HCID 673934282-(4-Iodo-imidazol-1-yl)-4-difluoromethyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine

Procedure

The title compound was prepared from 2-chloro-4-difluoromethyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine (example A.3) (1.24 g, 4.0 mmol) and commercially available 4-iodo-imidazole (0.85 g, 4.4 mmol) according to the general procedure Ia. Obtained as a light brown solid (1.77 g, 95%). MS (ISP) 468.0 [(M+H)+]; mp 173° C.

Sources & evidence

ORD record
ord-bff087afbfe14d16a71f32676da504fb
Source dataset
uspto-grants-2011_09
Patent number
US08012986B2

Reaction notes

Loading…